Start of funding 01.07.2023

Integration of Known Operators into a Deep Neural Network for Enhanced HR-pQCT Bone Imaging

Prof. Dr. Andreas Maier
Friedrich-Alexander-University of Erlangen-Nuremberg
Computer Science Department 5 - Pattern Recognition Lab

Prof. Dr. Andrew Burghardt
University of California, San Francisco
School of Medicine



This interdisciplinary research project is a collaboration between Prof. Dr. Maier's lab at Friedrich-Alexander University Erlangen-Nuremberg and Prof. Dr. Burghardt's lab at the University of California, San Francisco. The joint work focuses on the application and enhancement of high-resolution peripheral quantitative computed tomography (HR-pQCT) - a clinically relevant technology for imaging bone structures and assessing diseases such as osteoporosis. Prof. Dr. Maier's lab has developed the PYRO-NN framework that embeds known operators into Tensorflow, enabling end-to-end trainable neural networks for CT image reconstruction. In collaboration with Prof. Dr. Burghardt, this framework is being tailored and applied to HR-pQCT. A critical part of this process is the integration of the ATRACT method - a reconstruction technique for small volumes with a limited field of measurement - into PYRO- NN. The aim is to optimize image reconstruction and interpretation. The expected outcome of this research is fundamental improvements in the spatial resolution of HR-pQCT images and increased accuracy in clinical interpretation and diagnosis.