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Start of funding 01.07.2007
MicroRNAs as therepeutic targets for heart failure
Prof. Dr. Dr. Stefan Engelhardt
University of Würzburg
Rudolf Virchow Zentrum/DFG-Forschungszentrum für Experimentelle Biomedizin
Dr. Mark Mercola
The Burnham Institute for Medical Research
Stem Cell and Regeneration Program
MicroRNAs (miRNAs) are endogenous RNA molecules, which post-transcriptionally regulate gene expression. By binding to specific mRNAs, miRNAs inhibit translation or lead to mRNA degradation. For the human genome more than 500 genes encoding microRNAs are curently known. The function of miRNAs in the adult myocardium is unclear. This transatlantic collaboration aims to combine unique techniques to screen mammalian miRNA libraries based on their function in primary cells. The resulting candidate miRNAs will undergo a complete cardiac validation ranging from in vitro studies and target identification to miRNA-transgenic mouse and miRNA-transfer in vivo.