Please select the desired project time frame:
- July 2026
- January 2026
- July 2025
- January 2025
- July 2024
- January 2024
- July 2023
- January 2023
- July 2022
- January 2022
- July 2021
- January 2021
- July 2020
- January 2020
- July 2019
- January 2019
- July 2018
- January 2018
- July 2017
- January 2017
- July 2016
- January 2016
- July 2015
- January 2015
- July 2014
- January 2014
- July 2013
- January 2013
- July 2012
- January 2012
- July 2011
- January 2011
- July 2010
- January 2010
- July 2009
- January 2009
- July 2008
- January 2008
- July 2007
- January 2007
- July 2006
- January 2006
- July 2005
- January 2005
- July 2004
- January 2004
- July 2003
- January 2003
- July 2002
- January 2002
- July 2001
- January 2001
Start of funding 01.01.2011
Increasing efficiency and robustness of in-vivo magnetic resonance spectroscopic imaging
Prof. Dr. Steffen J. Glaser
Technische Universität München
Prof. Daniel Spielman
Stanford University
Department of Radiology - Lucas Center
Magnetic resonance spectroscopic imaging (MRSI) allows non-invasive measurement of metabolite concentrations in live animal models and humans (in vivo). It is used to diagnose and monitor metabolic disorders and tumours. MRSI usually suffers from low sensitivity and long measurement time. Advent of hyperpolarization technique allows us to apply 13C MRSI for in-vivo measurements with a signal enhancement of more than 10,000-fold with no background signal, enabling the real-time detection of metabolism in a short time. However, the strong hyperpolarized signal decays over time and is diminished by the MRSI measurement. Therefore MRSI with hyperpolarized substances requires efficient and optimized hardware and measurement methods. This research cooperation aims at improving the efficiency and robustness of hyperpolarized 13C MRSI methods via numerical optimization of radiofrequency (RF) pulses, a main component of MR measurements.