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Start of funding 01.01.2015
In Vitro Model Systems of Mitotic Spindle positioning
Prof. Dr. Andreas Bausch
Technische Universität München
Prof. Dr. Daniel Fletcher
University of California, Berkeley
Department of Bioengineering
The grand goal of understanding the molecular basis of cell behavior depends in part on having a molecular ‘parts list’ detailing the identities, concentrations, and post-translational modifications of the molecules involved, but mixing those molecules together at random is unlikely to ignite the spark of life. Rather, additional information is needed to describe how the molecules are connected to each other and to the larger cellular context. The reconstitution of functional modules in vitro has proven to be a very promising route to address the underlying principles of biological self-organization. In this project the reconstitution of mitotic spindle of oocytes in deformable vesicles is planned, in order to determine the underlying physical principles.